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Updated: Mar 1, 2026

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El paradigma de la biopelícula: Un hito, no el destino

Thomas Bjarnsholt¹, Claus Lex², Phil Stewart³

¹Costerton Biofilm Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark.

|February 27, 2026

Abstract:

Biofilms have profoundly shaped our understanding of chronic infection, yet their explanatory reach is limited. This commentary argues that chronicity emerges from a host-pathogen partnership, where host-derived structural, metabolic, immune, and systemic constraints define persistence, tolerance, and treatment responses beyond microbial architecture alone.

Palabras clave:

infecciones crónicas biopelículas interacciones huésped-patógeno tolerancia microbiana tratamiento de infecciones

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