Micropunciones Orgánicas Activadas por NIR Basadas en Agregados J para Acelerar la Curación de Heridas Infectadas

It is imperative to provide timely and effective treatment for bacterially infected wounds to prevent progression to more severe pathological conditions. Herein, we report a near-infrared (NIR)-activated nanoassembly (BC@P) integrating dual functions of bactericidal activity and tissue repair. The nanoassembly is facilely fabricated via the self-assembly of organic photothermal molecules B(TIBC)₂, natural antioxidant molecules curcumin, and biocompatible eight-arm polyethylene glycol (8-arm-PEG). B(TIBC)₂ is rationally designed with an acceptor-donor-acceptor (A-D-A) structure and tailored photothermal activity; moreover, it undergoes assembly induced J-aggregation, leading to a red-shifted absorption tail extending into the NIR-II region. Consequently, BC@P exhibits broadened NIR absorption, favorable photothermal conversion efficiency (53.1%), efficient NIR-II emission, and robust antioxidative capacity. When integrated into a hyaluronic acid-based microneedle (MN) patch, BC@P efficiently penetrates the skin barrier to eradicate wound-resident bacteria, modulate the inflammatory response, and accelerate the healing of bacterial-infected wounds with excellent biosafety. This work not only presents a promising "kill-and-repair" platform for infected wound therapy but also provides a guiding paradigm for the design of J-aggregate scaffolds in biological NIR-II imaging applications.