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Relación entre el cáncer de mama y la metformina: una revisión bibliométrica
Zhaoning Wang1, Fangrui Zhao, Linlin Wang
1Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.
Medicine
|February 27, 2026
Resumen
El análisis bibliométrico revela una creciente investigación sobre la metformina
Área de la Ciencia:
- Oncología
- Endocrinología
- Bibliometría
Sus antecedentes:
- La diabetes tipo 2 y el cáncer de mama comparten una relación compleja.
- La metformina puede reducir la incidencia y la mortalidad del cáncer en pacientes con diabetes tipo 2.
Objetivo del estudio:
- Analizar las tendencias de investigación sobre fármacos para la diabetes, específicamente la metformina, en el tratamiento del cáncer de mama.
- Identificar lagunas de investigación y direcciones futuras.
Principales métodos:
- Análisis bibliométrico de 1080 publicaciones (2004-2024).
- Datos obtenidos de Web of Science Core Collection y PubMed.
- Se examinaron tendencias de publicación, países, instituciones, autores y palabras clave principales.
Principales resultados:
- Se observa un aumento de las publicaciones a partir de 2008.
- EE. UU. y China son las principales naciones investigadoras.
- Los términos clave incluyen "cáncer de mama", "riesgo", "metformina" y "crecimiento".
Conclusiones:
- La investigación sobre la metformina para el cáncer de mama se está expandiendo pero se limita a estudios mecanicistas y retrospectivos.
- La dosis clínica óptima sigue sin estar clara, lo que requiere más investigación experimental.
- La metformina muestra potencial en el manejo de la interacción entre la diabetes y el cáncer de mama.
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