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Involucro extramidal bilateral en germinoma intracraneal: lecciones diagnósticas de una presentación compleja
Fei He1,2, Renato P Munhoz1,2, Suneil K Kalia2,3
1University of Toronto, Temerty Faculty of Medicine, Department of Medicine, Division of Neurology, Toronto ON, Canada.
Arquivos de neuro-psiquiatria
|February 27, 2026
Resumen
Este reporte de caso detalla un germinoma intracraneal raro que se presenta con ansiedad y déficits neurológicos. El diagnóstico temprano es crucial para el tratamiento efectivo de este tumor cerebral poco común.
Área de la Ciencia:
- Neurooncología; Neuropatología; Radiología
Sus antecedentes:
- Los germinomas intracraneales son tumores raros que a menudo afectan a hombres jóvenes. Los síntomas inespecíficos como la ansiedad y los déficits cognitivos pueden retrasar el diagnóstico.
Objetivo del estudio:
- Presentar un caso de germinoma intracraneal con síntomas de presentación inusuales. Resaltar los desafíos diagnósticos y enfatizar la importancia de la detección temprana.
Principales métodos:
- Presentación de caso de un hombre de 25 años con síntomas neurológicos y psiquiátricos subagudos. La resonancia magnética (RM) reveló lesiones multifocales y degeneración Walleriana. La biopsia cerebral confirmó germinoma intracraneal.
Principales resultados:
- El paciente se presentó con ansiedad, déficits cognitivos, hipernatremia y hemiparesis. La resonancia magnética mostró lesiones en los ganglios basales, fórnices y región pineal. La biopsia confirmó germinoma intracraneal a pesar de marcadores tumorales normales.
Conclusiones:
- El germinoma intracraneal puede presentarse con síntomas inespecíficos, imitando otras condiciones neurológicas. El diagnóstico oportuno a través de imágenes avanzadas y biopsia es esencial para resultados favorables. Este caso subraya la necesidad de un alto índice de sospecha en adultos jóvenes con síntomas neurológicos y psiquiátricos inexplicables.
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