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Combinatorial Gene Control02:33

Combinatorial Gene Control

9.8K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.8K
Cellular Differentiation00:57

Cellular Differentiation

5.9K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.9K
DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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9.7K
Genetic Material01:20

Genetic Material

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Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.
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Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

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In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
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Video Experimental Relacionado

Updated: Mar 1, 2026

The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy
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The Modular Design and Production of an Intelligent Robot Based on a Closed-Loop Control Strategy

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Evolvoid: un algoritmo genético para dar forma a constructos celulares óptimos

Piera Mancini1, Flavio Fontana1,2, Ermes Botte1,2

  • 1Research Center "E. Piaggio", University of Pisa, Largo Lucio Lazzarino 1, 56122, Pisa, Italy.

Journal of biological engineering
|February 27, 2026
PubMed
Resumen
Este resumen es generado por máquina.

Evolvoid, una nueva canalización computacional, utiliza algoritmos genéticos para crear constructos celulares 3D virtuales. Este método in silico rentable optimiza los modelos celulares para el descubrimiento de fármacos y la investigación biológica.

Palabras clave:
constructos celulares 3DGemelos digitalesAlgoritmos genéticosModelos in silico

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Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
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Área de la Ciencia:

  • Biología Computacional
  • Biofísica

Sus antecedentes:

  • Los modelos celulares precisos son cruciales para la función tisular y el descubrimiento de fármacos.
  • Los modelos in vitro actuales (esferoides, organoides) son caros, de bajo rendimiento y carecen de reproducibilidad.
  • Evolvoid es una canalización computacional que utiliza algoritmos genéticos para generar constructos celulares 3D virtuales.

Objetivo del estudio:

  • Desarrollar un método rentable y reproducible para diseñar modelos celulares 3D.
  • Optimizar las morfologías de los constructos celulares virtuales simulando principios biofísicos.
  • Reducir la dependencia de modelos in vitro y animales en la investigación.

Principales métodos:

  • Integra simulaciones de elementos finitos con principios evolutivos.
  • Emplea algoritmos genéticos para evolucionar poblaciones de formas aleatorias.
  • Utiliza una función de aptitud basada en la minimización de la energía superficial y la viabilidad celular bajo gradientes de oxígeno.

Principales resultados:

  • Evolvoid genera constructos virtuales 3D similares a esferoides con morfologías optimizadas.
  • La función de aptitud incorpora principios termodinámicos, transporte de nutrientes y captación celular.
  • Los individuos evolucionados exhiben formas y tamaños similares a los esferoides in vitro.
  • La entropía de Shannon rastrea la creciente complejidad del genoma, consistente con la dinámica evolutiva.

Conclusiones:

  • Evolvoid es una plataforma modular, escalable y ajustable para el diseño in silico de modelos celulares 3D.
  • Permite la creación de gemelos digitales de alta fidelidad de sistemas biológicos.
  • Apoya los avances en tecnologías de laboratorio en un portátil y Nuevas Metodologías de Ensayo (NAMs).