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Carcinoma poco cohesivo que afecta difusamente a todo el tracto gastrointestinal: reporte de un caso
Wei Gao1, Yusheng Yang2, Xinyi Hu1
1Department of Gastroenterology, Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 746, Zhongsanzhong Road, Songjiang District, Shanghai, 201600, China.
Discover oncology
|February 28, 2026
Resumen
Un caso raro de carcinoma poco cohesivo (PCC) afectó difusamente a todo el tracto gastrointestinal en un hombre de 64 años. Este agresivo cáncer se presentó con lesiones gástricas y duodenales, lo que resalta la importancia de una evaluación diagnóstica integral.
Área de la Ciencia:
- Gastroenterología
- Oncología
- Patología
Sus antecedentes:
- El cáncer gástrico es una importante preocupación de salud mundial, que se clasifica como la cuarta causa principal de muerte por cáncer en todo el mundo.
- Un hombre de 64 años se presentó con dolor periumbilical posprandial, indicativo de posible patología gastrointestinal.
Objetivo del estudio:
- Informar un caso extremadamente raro de carcinoma poco cohesivo (PCC) con afectación difusa del tracto gastrointestinal.
- Destacar los desafíos diagnósticos y las características histológicas de esta rara neoplasia maligna.
Principales métodos:
- Estudios de tomografía computarizada (TC) abdominal con contraste.
- Esófagogastroduodenoscopia y colonoscopia.
- Tinción con hematoxilina-eosina (HE) y análisis inmunohistoquímicos para el diagnóstico definitivo.
Principales resultados:
- La TC reveló engrosamiento del antro gástrico y ganglios linfáticos agrandados.
- La endoscopia identificó lesiones tumorales en el estómago y el duodeno, con posibles cambios inflamatorios en el íleon y el colon.
- El análisis histopatológico confirmó adenocarcinoma invasivo intramucoso poco diferenciado, diagnosticado como Carcinoma Poco Cohesivo (PCC) con implantación difusa de la mucosa en todo el tracto gastrointestinal.
Conclusiones:
- El carcinoma poco cohesivo (PCC) es un subtipo altamente maligno de adenocarcinoma.
- La afectación difusa de todo el tracto gastrointestinal por PCC es excepcionalmente rara y plantea desafíos diagnósticos y terapéuticos.
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