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Progreso, potencial y escollos de la ketamina como tratamiento para la depresión y trastornos relacionados
Diana K Orsini1,2, Sara Di Luch1,2, Gabrielle F M Lovell1,2
1Poul Hansen Family Centre for Depression, University Health Network, Toronto, ON , Canada.
Expert opinion on pharmacotherapy
|February 28, 2026
Resumen
La ketamina muestra promesa para los trastornos psiquiátricos, con creciente evidencia para el tratamiento de la depresión. Las actualizaciones de investigación cubren la eficacia, seguridad, vías de administración y posibles nuevos usos para esta novedosa terapia.
Área de la Ciencia:
- Psiquiatría
- Farmacología
- Neurociencia
Sus antecedentes:
- La ketamina es un tratamiento emergente para los trastornos psiquiátricos.
- La investigación reciente ha ampliado la comprensión de su potencial terapéutico.
Objetivo del estudio:
- Proporcionar una revisión narrativa de los avances recientes en la investigación de la ketamina.
- Resumir nuevos datos de eficacia, seguridad y administración.
- Discutir posibles nuevas indicaciones y desafíos.
Principales métodos:
- Revisión narrativa de ensayos clínicos y estudios de efectividad en el mundo real.
- Síntesis de datos de seguridad, incluido el tratamiento a largo plazo.
- Análisis de rutas de administración alternativas y optimización de protocolos.
Principales resultados:
- La fuerte evidencia respalda la ketamina y la esketamina para la depresión.
- Crecientes datos de seguridad, incluido el uso a largo plazo, son tranquilizadores.
- Datos preliminares sugieren eficacia para el trastorno bipolar, TEPT y TOC.
Conclusiones:
- La ketamina demuestra una promesa significativa para diversas afecciones psiquiátricas.
- Se necesita más investigación para optimizar los protocolos de tratamiento y explorar nuevas indicaciones.
- Los desafíos incluyen el descegamiento funcional, el sesgo y el costo.
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