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Valor científico y limitaciones de las dietas purificadas en la investigación con animales

Fangrui Guo¹, John P Kastelic², Lixin Wen¹

¹Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China.

Cell metabolism

|February 28, 2026

Abstract:

Purified diets widely used in rodent studies lack bioactive compounds from whole foods that affect gut microbiota and host physiology; this may cause contradictory outcomes in some studies. Prioritizing biological relevance over compositional reproducibility and reassessing dietary models are crucial for improving scientific rigor.

Palabras clave:

dietas para roedores microbiota intestinal relevancia biológica reproducibilidad rigor científico

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