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Escleritis nodular asociada a crizotinib en un adolescente

Mennatullah Elfwwal¹, Douglas S Hawkins², Laura C Huang¹

¹Department of Ophthalmology, University of Washington, Seattle, Washington; Division of Ophthalmology, Seattle Children's Hospital, Seattle, Washington.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

|February 28, 2026

Abstract:

We report the case of a 17-year-old girl with history of anaplastic large-cell lymphoma on crizotinib therapy who presented with pain and blurred vision in the left eye. Examination demonstrated nodular non-necrotizing anterior scleritis in the left eye. The patient initially improved with oral glucocorticoid treatment until she developed nodular non-necrotizing anterior scleritis in the right eye during taper of this medication. Discontinuation of crizotinib allowed the patient to taper off glucocorticoid treatment, with subsequent resolution of scleritis.

Palabras clave:

crizotinib escleritis linfoma anaplásico de células grandes efecto secundario ocular tratamiento oftalmología oncología farmacología

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