Video Experimental Relacionado

Updated: Apr 26, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

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Corea subaguda de inicio tardío

Pedro Fraiman1, Kaliny Oliveira Peixoto2, Rodrigo Alencar E Silva2

  • 1Division of General Neurology, Ataxia and Neurorheumatology Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, Sao Paulo, Brazil pedro.fraiman@unifesp.br.

Practical neurology
|April 24, 2026
PubMed

Una mujer de 71 años presentó cambios conductuales de inicio tardío, diagnosticados inicialmente como trastorno bipolar, seguidos 4 años después por corea generalizada y pérdida de peso. La exploración mostró movimientos hiperquinéticos con características frontales y oculomotoras. Una resonancia magnética cerebral reveló hiperintensidades bilaterales estriatales en la secuencia T2 FLAIR. El suero y el líquido cefalorraquídeo resultaron positivos para anticuerpos contra la proteína mediadora de respuesta a la colapsina 5/CV2 y anticuerpos antinucleares neuronales tipo 1/Hu, y las imágenes identificaron una neoplasia torácica subyacente. La paciente no respondió a la inmunoterapia y falleció poco después. Este caso destaca la encefalitis estriatal paraneoplásica como una causa importante de corea de inicio tardío. Los síntomas psiquiátricos pueden preceder a las características neurológicas por varios años, y las señales de alerta, como la progresión subaguda, los síntomas sistémicos y los cambios característicos en las imágenes de resonancia magnética, deben motivar una investigación temprana de anticuerpos neuronales y neoplasias.

Palabras clave:
MOVEMENT DISORDERSNEUROIMMUNOLOGYPARANEOPLASTIC SYNDROME

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