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La farmacogenética de la tolbutamida y la controversia del UGDP

J Scott, P L Poffenbarger

    JAMA
    |July 6, 1979
    PubMed
    Resumen

    Los factores genéticos que influyen en el metabolismo de la tolbutamida pueden explicar los efectos adversos observados en el estudio del Programa de Diabetes del Grupo Universitario (UGDP). Los metabolizadores lentos, un segmento significativo de la población, podrían acumular niveles tóxicos de fármacos, lo que podría afectar los resultados del estudio.

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