Aumento de los niveles séricos de lactato deshidrogenasa en el infarto renal

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G G Winzelberg, J D Hull, J W Agar

|July 20, 1979

Resumen

Un aumento significativo en la lactato deshidrogenasa sérica (LDH) sin aumentos sustanciales en SGOT o fosfatasa alcalina sugiere un infarto renal. Este hallazgo ayuda a diagnosticar problemas renales cuando se descartan otras causas.

Área de la Ciencia:

Nefrología Nefrología.
Medicina de diagnóstico La medicina de diagnóstico es la medicina de diagnóstico.
La bioquímica es la bioquímica.

Sus antecedentes:

Los niveles de enzimas séricas son cruciales para diagnosticar el daño de órganos.
El diagnóstico del infarto renal puede ser difícil, ya que requiere biomarcadores específicos.
El aumento de la lactato deshidrogenasa (LDH) es un indicador general de daño tisular.

Objetivo del estudio:

Para evaluar el significado diagnóstico de la LDH sérica elevada aislada en el infarto renal.
Para diferenciar el infarto renal de otras afecciones que causan elevación de la LDH.

Principales métodos:

Análisis de la serie de casos de cinco pacientes con infarto renal confirmado.
Análisis de los niveles de enzimas séricas, incluyendo LDH, SGOT y fosfatasa alcalina.
Revisión de las historias de los pacientes y factores etiológicos para el infarto renal.

Principales resultados:

Cinco pacientes con infarto renal mostraron niveles séricos de LDH marcadamente elevados.
Estas elevaciones fueron desproporcionadas a los aumentos en SGOT y fosfatasa alcalina.
Se excluyeron las causas comunes de elevación aislada de la LDH, como la hemólisis y el infarto de miocardio.

Conclusiones:

Una LDH sérica notablemente elevada, con cambios mínimos en SGOT y fosfatasa alcalina, es un valioso indicador de diagnóstico para el infarto renal.
Este patrón enzimático puede ayudar a identificar el infarto renal, particularmente cuando está asociado con afecciones como arritmias auriculares o aneurismas aórticos.

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