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Prueba de dipiridamol-aspirina en la trombosis venosa recurrente
Lancet (London, England)
|December 20, 1980
Resumen
El dipiridamolo (DPY) y la aspirina (ASA) redujeron significativamente la trombosis venosa nueva en pacientes con tromboembolismo venoso recurrente (ETVR) al mejorar la supervivencia plaquetaria. Esta terapia de combinación ofrece un enfoque prometedor para el manejo de RVTE.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Hematología Hematología.
- Farmacología clínica Farmacología clínica.
Sus antecedentes:
- El tromboembolismo venoso recurrente (TVRE) plantea un desafío clínico significativo.
- La supervivencia plaquetaria anormal está implicada en la fisiopatología de RVTE.
- Los tratamientos existentes para la ETRV tienen limitaciones y efectos secundarios.
Objetivo del estudio:
- Evaluar la eficacia del dipiridamolo (DPY) en combinación con aspirina (ASA) en la prevención de la aparición de una nueva trombosis venosa en pacientes con ETVR.
- Evaluar el efecto de DPY-ASA en la supervivencia plaquetaria en pacientes con RVTE.
- Para comparar la incidencia de trombosis venosa nueva entre los pacientes tratados con DPY-ASA y el placebo.
Principales métodos:
- Estudio prospectivo, doble ciego, controlado con placebo, en el que participaron 38 pacientes con ETVR.
- Los pacientes recibieron DPY (100 mg/día) más ASA (1200 mg/día) o placebo.
- La supervivencia plaquetaria se midió utilizando el etiquetado 51Cr de las plaquetas autólogas cada 6 meses durante 18 meses.
Principales resultados:
- El grupo DPY-ASA experimentó significativamente menos eventos de trombosis venosa nueva (1/19) en comparación con el grupo placebo (7/19) (p<0.05).
- El tratamiento con DPY-ASA condujo a un aumento de la supervivencia plaquetaria, mientras que el placebo no lo hizo.
- Las úlceras pépticas ocurrieron en 2 pacientes que recibieron DPY-ASA.
Conclusiones:
- DPY en combinación con ASA disminuye la frecuencia de nuevas trombosis venosa en pacientes con RVTE y la supervivencia plaquetaria anormal.
- La terapia con DPY-ASA mejora la supervivencia plaquetaria, lo que sugiere un mecanismo para su efecto antitrombótico.
- Si bien es eficaz, debe considerarse el posible efecto secundario de las úlceras pépticas.
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