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Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung
Published on: June 5, 2012
¿Se produce la infección cruzada de pseudomonas entre pacientes con fibrosis quística?
Lancet (London, England)
|September 25, 1982
Resumen
La exposición ambiental es la principal fuente de cepas de Pseudomonas aeruginosa para los pacientes con fibrosis quística (FC). La infección cruzada significativa entre pacientes con FQ requiere un contacto cercano y prolongado.
Área de la Ciencia:
- Microbiología Médica Microbiología médica.
- Enfermedades infecciosas Enfermedades infecciosas.
- Pulmonología Pulmonología.
Sus antecedentes:
- Pseudomonas aeruginosa es un patógeno oportunista significativo en pacientes con fibrosis quística (FQ).
- Comprender la dinámica de transmisión de P. aeruginosa es crucial para el control de la infección en el cuidado de la FQ.
Objetivo del estudio:
- Investigar las fuentes y los patrones de transmisión de las infecciones respiratorias por P. aeruginosa en pacientes con fibrosis quística.
- Determinar el papel del contacto con el paciente frente a la adquisición ambiental en la colonización de P. aeruginosa.
Principales métodos:
- Tipología bacteriana de aislamientos de P. aeruginosa de pacientes con FQ durante 12 meses.
- Utilizó la serología y la producción de pyocina para la diferenciación de cepas.
- Datos de cepas correlacionados con los niveles de contacto de los pacientes y las relaciones familiares.
Principales resultados:
- Se identificó una cepa de P. aeruginosa en cuatro pacientes no relacionados, lo que sugiere la adquisición ambiental.
- Seis pares de hermanos compartían cepas idénticas, pero las cepas entre pares de hermanos eran distintas.
- No se encontró evidencia de una infección cruzada generalizada entre los pacientes no contactados.
Conclusiones:
- El medio ambiente parece ser la fuente predominante de cepas de P. aeruginosa que colonizan a los pacientes con FQ.
- La infección cruzada entre pacientes con fibrosis quística requiere contacto prolongado e íntimo.
- Las medidas de vigilancia y control ambiental pueden ser vitales para el manejo de P. aeruginosa en entornos de FQ.
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