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Terapia con ketoconazol para el cáncer de próstata avanzado
Lancet (London, England)
|August 25, 1984
Resumen
El ketoconazol trató eficazmente el cáncer de próstata, reduciendo el dolor y reduciendo la testosterona. La mayoría de los pacientes lograron remisión con efectos secundarios limitados, mostrando una promesa para este tratamiento.
Área de la Ciencia:
- Oncología Oncología.
- Farmacología Farmacología.
Sus antecedentes:
- El cáncer de próstata sigue siendo una preocupación importante para la salud.
- Las terapias hormonales son cruciales para el manejo del cáncer de próstata avanzado.
Objetivo del estudio:
- Evaluar la eficacia y tolerabilidad del ketoconazol en el tratamiento del cáncer de próstata.
Principales métodos:
- Quince pacientes con cáncer de próstata comprobado por biopsia recibieron cetoconazol (400 mg cada 8 horas).
- La duración del tratamiento fue de al menos 6 meses para la mayoría de los participantes.
Principales resultados:
- El ketoconazol redujo significativamente la necesidad de analgésicos.
- La fosfatasa ácida prostática sérica se normalizó y los niveles de testosterona disminuyeron.
- Trece de los catorce pacientes evaluables lograron la remisión después de 6 meses.
Conclusiones:
- El ketoconazol demuestra una eficacia significativa en el tratamiento del cáncer de próstata.
- El tratamiento fue bien tolerado con efectos secundarios mínimos.
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