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La hormona adrenocorticotrópica puede ser transportada directamente desde la pituitaria al cerebro
Science (New York, N.Y.)
|October 31, 1980
Resumen
Las hormonas pituitarias como la hormona adrenocorticotrópica (ACTH) pueden llegar directamente al cerebro. ACTH elevada en las ovejas.
Área de la Ciencia:
- La neuroendocrinología en neuroendocrinología.
- Fisiología Fisiología Fisiología.
Sus antecedentes:
- El transporte directo de las hormonas pituitarias al cerebro es un tema muy debatido.
- Comprender esta vía es crucial para la función cerebral y la investigación de enfermedades.
Objetivo del estudio:
- Para investigar la hipótesis de que las hormonas pituitarias se entregan directamente al cerebro.
- Para medir las concentraciones de hormona adrenocorticotrópica (ACTH) en la sangre venosa cerebral.
Principales métodos:
- Muestreo de sangre simultáneo de la arteria carótida, el seno sagital y la vena yugular en ovejas despiertas.
- Inducción eléctrica de las convulsiones para estimular la secreción de ACTH.
- Análisis de la concentración plasmática de ACTH a intervalos precisos después de la convulsión.
Principales resultados:
- Después de la convulsión, los niveles de ACTH en el seno sagital con frecuencia excedieron los niveles de la carótida y la yugular.
- Esto sugiere que el ACTH derivado de la pituitaria entra en los lechos capilares cerebrales y sale a través del seno sagital.
- En una oveja hipofiséctomizada, la elevación del ACTH del seno sagital después de la convulsión indicó la liberación de ACTH derivada del cerebro.
Conclusiones:
- La evidencia apoya la entrega directa de ACTH pituitario al cerebro a través de los capilares cerebrales.
- El propio cerebro también puede liberar ACTH o sustancias similares a ACTH.
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