Video Experimental Relacionado
Updated: Jul 20, 2026
09:07
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
El oncogén del carcinoma de vejiga del EJ humano es homólogo del gen ras del virus del sarcoma de Harvey
Nature
|June 10, 1982
Resumen
El oncogén del carcinoma de vejiga humana (EJ) es homólogo al oncogén del virus del sarcoma de Harvey (ras). Este hallazgo, localizado en un fragmento específico de ADN, sugiere un mecanismo compartido en el desarrollo del cáncer.
Área de la Ciencia:
- Biología molecular La biología molecular.
- Oncología Oncología.
- Virología Virología.
Sus antecedentes:
- Los oncogenes retrovirales están implicados en el desarrollo del cáncer.
- Los estudios de transfección definen las secuencias genéticas transformadoras.
- El oncogén del virus del sarcoma de Harvey (ras) es un oncogén conocido.
Objetivo del estudio:
- Investigar las homologías entre los oncogenes retrovirales y las secuencias transformadoras.
- Para identificar el oncogén específico en el carcinoma de la vejiga humana (EJ).
- Para comparar el oncogén del EJ con el oncogén del virus del sarcoma de Harvey (ras).
Principales métodos:
- Examen de homología entre oncogenes retrovirales y secuencias de transformación definidas por transfección.
- Análisis estructural del carcinoma de la vejiga humana (EJ) oncogénico.
- La hibridación de la sonda de ADN para detectar transcripciones.
Principales resultados:
- El oncogén del carcinoma de vejiga humana (EJ) muestra homología con el oncogén del virus del sarcoma de Harvey (ras).
- La región de homología se limita a un fragmento de 3,0 kilobases SacI del oncogén de la EJ.
- Tanto las sondas de EJ como las de ADN ras identificaron transcripciones similares en transfectantes de la línea celular del carcinoma de vejiga.
Conclusiones:
- El oncogén del carcinoma de vejiga humana (EJ) está estrechamente relacionado con el oncogén del virus del sarcoma de Harvey (ras).
- Esta homología sugiere un origen o mecanismo común para estos oncogenes en el cáncer.
- Investigaciones adicionales sobre la EJ y los oncogenes ras podrían aclarar las vías de desarrollo del cáncer.
Videos de Conceptos Relacionados
02:38The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
02:38The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...