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El oncogén del carcinoma de vejiga del EJ humano se encuentra en el brazo corto del cromosoma 11
Science (New York, N.Y.)
|February 4, 1983
Resumen
El oncogén del carcinoma de vejiga humano se localizó en el cromosoma 11. Este gen es homólogo al oncogén v-Ha-ras del virus del sarcoma murino Harvey.
Área de la Ciencia:
- Genética La genética.
- Oncología Oncología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Se identificó la secuencia de ADN transformador de las células de carcinoma de vejiga de EJ.
- El oncogén del virus del sarcoma murino de Harvey v-Ha-ras es un oncogén conocido.
Objetivo del estudio:
- Para determinar la ubicación cromosómica del homólogo celular humano del carcinoma de la vejiga del EJ transformando la secuencia de ADN.
- Para investigar la relación entre esta secuencia humana y el v-Ha-ras oncogene.
Principales métodos:
- El análisis de Southern blot se realizó en el ADN de células híbridas de roedores humanos y roedores.
- El ADN fue analizado para identificar secuencias homólogas.
Principales resultados:
- El homólogo celular humano de la secuencia de ADN transformadora se localizó en el brazo corto del cromosoma humano 11.
- Se encontró que este locus contenía secuencias humanas homólogas al oncogén v-Ha-ras del virus del sarcoma murino Harvey.
Conclusiones:
- El oncogén del carcinoma de vejiga humano se encuentra en el cromosoma 11.
- La secuencia humana identificada es homóloga al oncogén v-Ha-ras, lo que sugiere un papel en el desarrollo del cáncer de vejiga.
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