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Fibrillas asociadas a la tembladera en la enfermedad de Creutzfeldt-Jakob
Nature
|December 1, 1983
Resumen
La tembladera y la enfermedad de Creutzfeldt-Jakob (ECJ) implican degeneración cerebral. Las fibrillas anormales (FAS) encontradas en los cerebros y el bazo infectados sugieren que pueden ser el agente infeccioso o una respuesta patológica.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Enfermedades infecciosas Enfermedades infecciosas.
- Patología Patología Patología.
Sus antecedentes:
- Las encefalopatías espongiformes transmisibles (ETS) como el scrapie y la ECJ causan neurodegeneración fatal.
- Los agentes infecciosos de estas enfermedades siguen sin identificarse, pero comparten propiedades físico-químicas.
- Las fibrillas anormales, denominadas fibrillas asociadas al scrapie (SAF, por sus siglas en inglés), se encuentran en preparaciones cerebrales infectadas con scrapie.
Objetivo del estudio:
- Para investigar la presencia de SAF en la enfermedad de Creutzfeldt-Jakob (ECJ) y el scrapie.
- Para determinar si las SAF están asociadas con la ECJ en casos humanos de transmisión experimental y de ocurrencia natural.
- Para examinar la presencia de SAF en el tejido del bazo, un sitio conocido de infectividad.
Principales métodos:
- Análisis de fracciones cerebrales de pacientes con ECJ (casos experimentales y naturales).
- Examen de extractos de bazo de animales infectados con scrapie o ECJ.
- Observación microscópica para la presencia de fibrillas asociadas a la tembladera.
Principales resultados:
- Se detectaron SAF en fracciones cerebrales de casos humanos de ECJ transmitidos experimentalmente y de ocurrencia natural.
- La FAA también se identificó en extractos de bazo de animales infectados con scrapie o ECJ.
- Los SAF estuvieron constantemente ausentes en los tejidos de los animales de control.
Conclusiones:
- La presencia de SAF en los tejidos del cerebro y el bazo asociados con el scrapie y la ECJ sugiere un fuerte vínculo.
- La FAA puede representar ya sea una respuesta patológica única a estas enfermedades o el propio agente infeccioso.
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