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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Partícula específica de la infección de las enfermedades poco convencionales por virus lentos
Science (New York, N.Y.)
|July 27, 1984
Resumen
Las fibrillas asociadas a la tembladera son marcadores específicos para las enfermedades poco convencionales por virus lentos. Estas fibrillas, que se encuentran en los cerebros y el bazo infectados, pueden ser el agente causal de estas afecciones neurodegenerativas.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Patología Patología Patología.
- Virología Virología.
Sus antecedentes:
- Las fibrillas asociadas a la tembladera (FAS) se identificaron inicialmente en los cerebros de ratones infectados con tembladera.
- Estas fibrillas únicas también se han detectado en otras especies y en enfermedades priónicas humanas.
Objetivo del estudio:
- Para determinar la presencia y la especificidad de las fibrillas asociadas a la tembladera en diversas condiciones neurológicas.
- Evaluar las SAF como posibles marcadores de diagnóstico y agentes etiológicos para enfermedades por virus lentos no convencionales.
Principales métodos:
- Se utilizó microscopía electrónica para examinar los tejidos del cerebro y el bazo de sujetos infectados y de control.
- Se realizaron análisis histopatológicos y ultrastructurales para identificar y caracterizar las fibrillas.
Principales resultados:
- Las SAF se encontraron consistentemente en ratones, hámsters y monos infectados con scrapie, así como en humanos con enfermedad de Creutzfeldt-Jakob y monos infectados con kuru.
- Estas fibrillas estaban ausentes en los cerebros de control con neuropatologías similares, lo que indica una alta especificidad.
- Los FAS también se detectaron en la tembladera preclínica y en el bazo de ratones infectados.
Conclusiones:
- Las fibrillas asociadas a la tembladera sirven como un marcador diagnóstico específico para enfermedades por virus lentos no convencionales, incluidas las enfermedades priónicas.
- La presencia de SAF en los tejidos afectados sugiere que pueden ser el agente etiológico responsable de estas enfermedades.
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