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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Anormalidades del intestino delgado en la esclerosis múltiple
Lancet (London, England)
|December 18, 1976
Resumen
Los pacientes con esclerosis múltiple (EM) muestran anomalías de la mucosa jejunal, que incluyen inflamación y atrofia villosa. El análisis ultrastructural reveló cambios estructurales finos significativos en el revestimiento del intestino delgado.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Neurología Neurología.
- Inmunología Inmunología.
Sus antecedentes:
- La esclerosis múltiple (EM) es una enfermedad inflamatoria crónica del sistema nervioso central.
- La posible participación del tracto gastrointestinal en la patogénesis de la EM sigue siendo un área de investigación.
Objetivo del estudio:
- Para investigar las características histológicas y ultrastructural de la mucosa jejunal en pacientes con esclerosis múltiple.
Principales métodos:
- Se obtuvieron biopsias de Jejunal de 12 pacientes con esclerosis múltiple.
- Se emplearon técnicas histológicas, ultrastructurales e inmunológicas de tejidos para el examen.
Principales resultados:
- La histología reveló una mucosa normal en 7 pacientes, con infiltración inflamatoria o atrofia villosa en 5.
- Se observaron anomalías ultrastructurales en 6 de 8 pacientes, incluidos cambios microvilosos, aumento de linfocitos y lisosomas, engrosamiento del tejido conectivo y macrófagos con material denso en electrones.
Conclusiones:
- Las anomalías de la mucosa jejunal están presentes en un subconjunto de pacientes con esclerosis múltiple.
- Estos hallazgos sugieren una posible participación gastrointestinal en la fisiopatología de la esclerosis múltiple.
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