Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Measurement of the [Formula: see text] cross section in pp collisions at [Formula: see text] TeVand limits on anomalous gauge couplings.

The European physical journal. C, Particles and fields·2017
Same author

Measurement of differential cross sections for Higgs boson production in the diphoton decay channel in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2016
Same author

Study of B Meson Production in p+Pb Collisions at √[S(NN)]=5.02 TeV Using Exclusive Hadronic Decays.

Physical review letters·2016
Same author

Measurement of the differential cross section for top quark pair production in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Measurements of the [Formula: see text][Formula: see text] production cross sections in the [Formula: see text] channel in proton-proton collisions at [Formula: see text] and [Formula: see text] and combined constraints on triple gauge couplings.

The European physical journal. C, Particles and fields·2015
Same author

Constraints on the pMSSM, AMSB model and on other models from the search for long-lived charged particles in proton-proton collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015

Video Experimental Relacionado

Updated: May 11, 2026

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
08:07

Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

Published on: May 19, 2020

Un gen no polimórfico de clase I en el complejo de histocompatibilidad mayor murino.

A L Mellor, E H Weiss, M Kress

    Cell
    |January 1, 1984
    PubMed
    Resumen

    El análisis de la secuencia de ADN revela genes no polimórficos de clase I en el locus Q10. Estos genes pueden codificar polipéptidos específicos del hígado, en contraste con los genes H-2K polimórficos.

    Más Videos Relacionados

    Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
    11:17

    Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

    Published on: March 10, 2021

    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
    09:32

    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

    Published on: October 15, 2021

    Videos de Experimentos Relacionados

    Last Updated: May 11, 2026

    Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry
    08:07

    Assessing the Expression of Major Histocompatibility Complex Class I on Primary Murine Hippocampal Neurons by Flow Cytometry

    Published on: May 19, 2020

    Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
    11:17

    Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

    Published on: March 10, 2021

    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
    09:32

    Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

    Published on: October 15, 2021

    Área de la Ciencia:

    • Inmunogenética La inmunogenética.
    • Biología Molecular Biología Molecular
    • La genómica es la genómica.

    Sus antecedentes:

    • Los genes de clase I juegan un papel crucial en las respuestas inmunes y las interacciones de la superficie celular.
    • El locus Qa2,3 en ratones alberga genes de clase I con funciones en gran parte desconocidas.
    • Investigaciones anteriores sugirieron la posible participación del gen Q10 en la transferencia de información genética en el locus H-2K.

    Objetivo del estudio:

    • Para analizar la secuencia de ADN del gen Q10 clase I de ratones C57BL/10.
    • Para comparar la secuencia Q10 con un clon de ADNc de ratones SWR/J.
    • Investigar las implicaciones estructurales y funcionales de las variaciones de secuencia en los genes de clase I.

    Principales métodos:

    • Secuenciación del ADN del gen Q10.
    • Comparación con un clon de ADNc del hígado (pH16).
    • Análisis de las estructuras de los exones y de los posibles productos proteicos.

    Principales resultados:

    • La secuencia del gen Q10 es casi idéntica a la del clon de ADNc pH16 de un haplotipo de ratón diferente.
    • El exón 5 exhibe una estructura inusual, lo que sugiere que el polipéptido puede no estar anclado en la membrana.
    • Los genes de clase I en el locus Q10 parecen no polimórficos, a diferencia de los genes H-2K.

    Conclusiones:

    • Las secuencias Q10 y pH16 probablemente representan genes aleloides no polimórficos de clase I.
    • Estos genes pueden codificar polipéptidos no caracterizados específicos del hígado.
    • La falta de polimorfismo sugiere que los genes del locus Q10 no son receptores del intercambio genético o están bajo una fuerte presión selectiva.