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Intracellular Refolding Assay
Published on: January 24, 2012
Regulación de la proteína de choque térmico 70 expresión génica por c-mycc
Nature
|November 15, 1984
Resumen
El producto del gen myc puede estimular la expresión génica de la proteína de choque térmico 70 (HSP70). Este hallazgo sugiere un papel para el myc en la regulación de las respuestas celulares, impactando potencialmente en el desarrollo del tumor.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Oncología Oncología.
- Reglamento genético Reglamento genético.
Sus antecedentes:
- El gen mic está implicado en varios tipos de cáncer.
- El producto del gen myc se localiza en el núcleo, lo que sugiere un papel en la regulación de la expresión génica.
- Se observa una expresión elevada de la proteína de choque térmico 70 (HSP70) en las líneas celulares tumorales.
Objetivo del estudio:
- Para investigar la relación funcional entre el producto del gen myc y la proteína de choque térmico 70 (HSP70) gene.
- Para determinar si el producto del gen mic puede influir en la expresión del gen HSP70.
Principales métodos:
- Genes quiméricos construidos utilizando el promotor hsp70 de Drosophila y las secuencias 5'-flanqueantes.
- Introdujo un gen c-myc de ratón reorganizado en las células.
- Se evaluó el efecto del producto del gen del micoma en la expresión de los genes quiméricos.
Principales resultados:
- El producto genético de un gen c-myc de ratón reorganizado estimuló la expresión de genes quiméricos que contienen el promotor Drosophila hsp70.
- Esta estimulación dependía de secuencias específicas de ADN ubicadas aguas arriba del sitio de inicio de la transcripción hsp70 (>200 bases).
Conclusiones:
- El producto del gen de mico puede influir directamente en la expresión del gen HSP70.
- Esta interacción involucra secuencias reguladoras ubicadas muy aguas arriba del inicio de la transcripción del gen HSP70.
- Estos hallazgos proporcionan información sobre los mecanismos moleculares por los cuales el myc puede contribuir a la tumorigénesis.
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