Video Experimental Relacionado
Updated: Aug 12, 2026
10:38
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
Enfermedad del suero inducida por Zomepirac. Un informe de dos casos en los que se han presentado dos casos
JAMA
|May 27, 1983
Resumen
Zomepirac sodio puede causar reacciones alérgicas graves, incluidas erupciones cutáneas, fiebre e hinchazón. Estos casos sugieren una reacción de hipersensibilidad tipo 3 al fármaco.
Área de la Ciencia:
- Farmacología Farmacología.
- Inmunología Inmunología.
- La medicina clínica es la medicina clínica.
Sus antecedentes:
- Zomepirac sodio es un fármaco antiinflamatorio no esteroideo (AINE).
- Las reacciones adversas a los medicamentos pueden variar de leves a graves.
- Comprender la hipersensibilidad inducida por medicamentos es crucial para la seguridad del paciente.
Objetivo del estudio:
- Informar de dos casos de reacciones adversas graves potencialmente relacionadas con el zomepirac sódico.
- Para caracterizar la presentación clínica y la respuesta inmunológica en estos pacientes.
- Proponer un mecanismo para la toxicidad observada.
Principales métodos:
- Observación del caso clínico y historia clínica detallada del paciente.
- Análisis de laboratorio que incluye recuentos de eosinófilos.
- Revisión de la literatura existente sobre el zomepirac y las reacciones alérgicas.
Principales resultados:
- Dos pacientes desarrollaron erupción tóxica aguda, fiebre, linfadenopatía, artralgias, angioedema de la mano y eosinophilia después de semanas de uso de zomepirac sodio.
- Las características clínicas sugieren una respuesta de hipersensibilidad significativa.
- La eosinofilia fue un hallazgo de laboratorio notable.
Conclusiones:
- Estos casos son consistentes con las reacciones alérgicas tipo 3 al zomepirac sodio.
- Zomepirac sodio puede inducir eventos adversos inmunomediados graves.
- Los médicos deben estar atentos a tales reacciones en pacientes que usan zomepirac sódico.
Videos de Conceptos Relacionados
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
01:27Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
01:26Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
01:17Poliomyelitis
Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
01:29Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
01:28Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...