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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
La respuesta del ácido gástrico y la gastrina al café descafeinado y una comida de peptona
JAMA
|July 17, 1981
Resumen
El café descafeinado estimula significativamente la secreción de ácido estomacal y la liberación de gastrina más que una comida proteica estándar. El componente activo específico en el café descafeinado sigue sin ser identificado.
Área de la Ciencia:
- Gastroenterología y Gastroenterología.
- Fisiología Humana Fisiología Humana.
- Farmacología Farmacología.
Sus antecedentes:
- La secreción de ácido gástrico y la liberación de gastrina son cruciales para la digestión.
- Varios estímulos pueden influir en estos procesos fisiológicos.
- El café descafeinado es una bebida común con posibles efectos fisiológicos.
Objetivo del estudio:
- Para comparar los efectos del café descafeinado y una comida de prueba de proteínas en la secreción de ácido gástrico y la liberación de gastrina.
- Para determinar la potencia relativa del café descafeinado como estimulante.
Principales métodos:
- A sujetos masculinos sanos (n=8) se les administraron dosis graduadas de café descafeinado y Bacto-peptona.
- Se midió la secreción de ácido gástrico mediante titulación intragástrica.
- Los niveles séricos de gastrina se determinaron mediante radioinmunoensayo.
Principales resultados:
- El café descafeinado estimuló tanto la secreción ácida como la liberación de gastrina de manera más potente que la bactopeptona.
- La producción máxima de ácido fue mayor con el café descafeinado (18,5 mmol / h) en comparación con la peptona (14,7 mmol / h).
- El aumento máximo de la gastrina sérica fue significativamente mayor con el café descafeinado (84,8 pg/mL) frente a la peptona (44,8 pg/mL).
Conclusiones:
- El café descafeinado es un estimulante más potente de la secreción de ácido gástrico y la liberación de gastrina que una comida de prueba de proteínas.
- Todavía no se han identificado los ingredientes específicos responsables del potente efecto estimulante del café descafeinado.
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