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Comparación entre el 25-hidroxicolecalciferol oral, la vitamina D y la luz ultravioleta como determinantes de la
Lancet (London, England)
|June 25, 1977
Resumen
El 25-hidroxicolecalciferol (25-OHD3) es más potente que la vitamina D para elevar los niveles de 25-hidroxivitamina D (25-OHD). Comprender estas relaciones dosis-respuesta ayuda a diagnosticar el estado de la vitamina D y pone de relieve las protecciones naturales contra la deficiencia.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Ciencias de la Nutrición Ciencias de la Nutrición
- El metabolismo es el metabolismo.
Sus antecedentes:
- La vitamina D es crucial para la homeostasis del calcio y la salud ósea.
- La medición de la 25-hidroxivitamina D circulante (25-OHD) es el estándar para evaluar el estado de la vitamina D.
- El 25-hidroxicolecalciferol oral (25-OHD3) y la vitamina D se usan para la suplementación, pero es importante comprender sus potencias relativas.
Objetivo del estudio:
- Para comparar la eficacia del 25-hidroxicolecalciferol oral (25-OHD3) y la vitamina D en el aumento de las concentraciones circulantes de 25-OHD.
- Para investigar las relaciones dosis-respuesta de ambos compuestos.
- Para evaluar la potencia terapéutica de 25-OHD3 en relación con la vitamina D.
Principales métodos:
- Más de 200 sujetos recibieron tratamiento oral a corto y largo plazo con 25-OHD3 o vitamina D.
- Los niveles circulantes de 25-OHD se midieron durante un período de 5 años.
- Las curvas de dosis-respuesta se analizaron utilizando un modelo de función de potencia.
Principales resultados:
- Se requirió diez veces más vitamina D que 25-OHD3 para lograr concentraciones plasmáticas equivalentes de 25-OHD.
- Los niveles plasmáticos de 25-OHD demostraron una relación de función de potencia con la dosis de ambos compuestos.
- Estos hallazgos sugieren una potencia terapéutica superior de 25-OHD3.3.
Conclusiones:
- El 25-hidroxicolecalciferol (25-OHD3) es significativamente más potente que la vitamina D para elevar los niveles de 25-OHD.
- Los datos de dosis-respuesta son valiosos para diagnosticar el estado de la vitamina D.
- Las restricciones sobre la 25-hidroxilación de la vitamina D y los efectos de la luz ultravioleta pueden ofrecer protección contra la deficiencia de vitamina D en invierno.
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