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Malformaciones congénitas inducidas por el laetrile
Science (New York, N.Y.)
|March 19, 1982
Resumen
El laetrile oral causó malformaciones esqueléticas en crías de hámster debido a la liberación de cianuro. El laetrile intravenoso no causó estos efectos, y el tiosulfato protegió contra la toxicidad del laetrile oral.
Área de la Ciencia:
- Toxicología Toxicología.
- Biología del desarrollo Biología del desarrollo.
- Farmacología Farmacología.
Sus antecedentes:
- El laetrile, un compuesto que se encuentra en los granos de albaricoque, ha sido investigado por sus posibles beneficios para la salud.
- Existen preocupaciones con respecto a la seguridad del laetrile, especialmente durante el embarazo.
- El destino metabólico y el potencial teratogénico del laetrile requieren una mayor aclaración.
Objetivo del estudio:
- Para investigar los efectos teratogénicos del laetrile administrado por vía oral e intravenosa en hámsters embarazadas.
- Para determinar el papel del cianuro en la embriopatía inducida por laetrile.
- Evaluar los efectos protectores del tiosulfato contra la toxicidad del laetrile.
Principales métodos:
- A los hámsters embarazadas se les administró laetrile por vía oral o intravenosa.
- El desarrollo esquelético de la descendencia fue examinado en busca de malformaciones.
- Las concentraciones de cianuro in situ se midieron en tejidos maternos y embrionarios.
- Se administró tiosulfato para evaluar su función protectora.
Principales resultados:
- La administración oral de laetrile resultó en malformaciones esqueléticas significativas en la descendencia.
- La administración intravenosa de laetrile no produjo efectos embriopáticos.
- El laetrile oral aumentó significativamente las concentraciones de cianuro in situ.
- La administración de tiosulfato protegió a los embriones de los efectos teratogénicos del laetrile oral.
Conclusiones:
- Es probable que los efectos teratogénicos del laetrile oral estén mediados por el cianuro liberado a través de la actividad de la beta-glucosidasa bacteriana.
- La administración intravenosa evita esta vía metabólica, evitando así la teratogenicidad.
- Estos hallazgos resaltan la importancia de la activación metabólica en la toxicidad del laetrile y sugieren un mecanismo para su potencial teratogénico.
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