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Video Experimental Relacionado

Updated: Jun 29, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

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Published on: July 31, 2016

Infusión continua de propranolol después de una cirugía abdominal.

H Smulyan, S E Weinberg, P J Howanitz

    JAMA
    |May 14, 1982
    PubMed
    Resumen

    La infusión intravenosa continua de propranolol mantuvo efectivamente los niveles terapéuticos durante la cirugía para pacientes con enfermedades cardíacas, evitando complicaciones y el síndrome de abstinencia de propranolol.

    Área de la Ciencia:

    • Cardiología Cardiología.
    • Farmacología Farmacología.
    • Medicina quirúrgica La medicina quirúrgica es la medicina quirúrgica.

    Sus antecedentes:

    • El tratamiento a largo plazo con clorhidrato de propranolol es común para las enfermedades del corazón.
    • Los procedimientos quirúrgicos en estos pacientes presentan riesgos relacionados con la retirada del bloqueo beta.

    Objetivo del estudio:

    • Evaluar la seguridad y eficacia de la infusión intravenosa continua de propranolol durante la cirugía abdominal.
    • Para determinar si este método previene las complicaciones perioperatorias y el síndrome de abstinencia del propranolol.

    Principales métodos:

    • Trece pacientes en tratamiento a largo plazo con propranolol se sometieron a 15 cirugías abdominales.
    • El propranolol se administró mediante infusión intravenosa continua en el postoperatorio.

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  • Las concentraciones séricas de propranolol fueron monitoreadas con frecuencia.

    • Principales resultados:

    • Los niveles terapéuticos de propranolol en suero se lograron dentro de un rango de dosis estrecho (promedio de 3,0 mg / h) en pacientes con función hepática y renal normal.
    • Todos los pacientes experimentaron ciclos postoperatorios libres de complicaciones atribuidas al bloqueo beta.
    • La infusión continua evitó el síndrome de abstinencia de propranolol.

    Conclusiones:

    • La infusión intravenosa continua de propranolol es un método seguro y eficaz para mantener los niveles terapéuticos durante los procedimientos quirúrgicos.
    • Este enfoque protege contra la estimulación simpática perioperatoria y previene el síndrome de abstinencia por propranolol.
    • Puede ser beneficioso en otras condiciones críticas donde la terapia oral está contraindicada.