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Propranolol como complemento en el tratamiento de la esquizofrenia
Lancet (London, England)
|September 17, 1977
Resumen
El propranolol puede ayudar a controlar los síntomas de la esquizofrenia crónica. En un estudio, los pacientes que recibieron propranolol mostraron una mejoría mayor que los que recibieron placebo, incluso después de un tratamiento a largo plazo con los principales tranquilizantes.
Área de la Ciencia:
- La psiquiatría es la psiquiatría.
- Farmacología Farmacología.
Sus antecedentes:
- Los síntomas de la esquizofrenia crónica a menudo persisten a pesar del tratamiento con los principales tranquilizantes.
- Explorar terapias adyuvantes es crucial para mejorar los resultados de los pacientes.
Objetivo del estudio:
- Evaluar la eficacia del propranolol como tratamiento complementario para la esquizofrenia crónica.
- Para evaluar la remisión de los síntomas en pacientes que no responden adecuadamente a los antipsicóticos convencionales.
Principales métodos:
- Se llevó a cabo un ensayo aleatorizado controlado con placebo de 12 semanas.
- 14 pacientes con esquizofrenia crónica recibieron propranolol o placebo además de su tratamiento existente con clorpromazina.
Principales resultados:
- Ambos grupos mostraron mejoría durante 12 semanas.
- El grupo de propranolol exhibió una mejora de los síntomas significativamente mayor en comparación con el grupo de placebo.
Conclusiones:
- El propranolol demuestra potencial como una terapia complementaria útil para el manejo de los síntomas persistentes de la esquizofrenia crónica.
- Se justifica una mayor investigación sobre los betabloqueantes para la esquizofrenia resistente al tratamiento.
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