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Alteraciones inducidas por virus en la homeostasis: alteración en las funciones diferenciadas de las células

M B Oldstone, Y N Sinha, P Blount

Science (New York, N.Y.)

|December 10, 1982

Resumen

El virus de la coriomeningitis linfocítica no citopática infecta las células pituitarias, reduciendo la síntesis de la hormona del crecimiento y causando retraso del crecimiento y hipoglucemia en ratones. Esto demuestra cómo los virus pueden interrumpir la homeostasis sin causar la muerte celular.

Área de la Ciencia:

Virología Virología.
Endocrinología Endocrinología.
Patología Patología Patología.

Sus antecedentes:

El virus de la coriomeningitis linfocítica (LCMV) es un virus no citopático.
La disfunción de la glándula pituitaria puede conducir a desequilibrios hormonales y trastornos del crecimiento.

Objetivo del estudio:

Para investigar el efecto de la infección no citopática por LCMV en la glándula pituitaria murina.
Comprender el mecanismo por el cual un virus no citopático puede causar enfermedades.

Principales métodos:

Infección de ratones con una cepa no citopática de LCMV.
Análisis de la morfología de la glándula pituitaria y síntesis de hormonas.
Evaluación del crecimiento y los niveles de glucosa en sangre en ratones infectados.

Principales resultados:

El LCMV se dirigió específicamente al lóbulo pituitario anterior en ratones.
La replicación del virus se produjo en las células productoras de la hormona del crecimiento.
La disminución de la síntesis de la hormona del crecimiento condujo al retraso del crecimiento y a la hipoglucemia.
No se observó evidencia de necrosis celular o inflamación.

Conclusiones:

Los virus no citopáticos pueden interrumpir la función celular (por ejemplo, la síntesis de hormonas) sin causar la muerte celular.
Esta interrupción de las funciones de "lujo" puede afectar la homeostasis y conducir a enfermedades.
El LCMV proporciona un modelo para la comprensión de la enfermedad inducida por virus a través del deterioro funcional en lugar de la lisis celular directa.

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