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Control del reflejo flexor del esfínter externo de la uretra en la paraplejía
Science (New York, N.Y.)
|June 11, 1982
Resumen
Los parapléjicos y tetrapléjicos experimentan parálisis muscular por debajo de las lesiones espinales. La investigación sugiere que un esfínter uretral externo hiperactivo, que se asemeja a un reflejo flexor, causa problemas de vaciado de la vejiga y posibles infecciones del tracto urinario.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Urología Urología Urología.
- Fisiología Fisiología Fisiología.
Sus antecedentes:
- Las lesiones de la médula espinal en parapléjicos y tetrapléjicos causan parálisis profunda del músculo esquelético.
- Un esfínter uretral externo hiperactivo (ESU) se desarrolla debajo de la lesión espinal, lo que dificulta el vaciado de la vejiga.
- Esta disfunción del SUE puede conducir a infecciones recurrentes del tracto urinario (ITU).
Objetivo del estudio:
- Para investigar la base neurofisiológica del esfínter uretral externo hiperactivo en la lesión de la médula espinal.
- Comprender los mecanismos subyacentes a la disfunción de la vejiga en la parálisis.
- Identificar posibles objetivos terapéuticos para el manejo de la hiperactividad de la ESU.
Principales métodos:
- Registros electrofisiológicos de la actividad motoneuronal en modelos animales (gatos).
- Análisis de las características de la descarga de la neurona motora durante la contracción de la ESU.
- Correlación de la actividad neural observada con las vías reflejas.
Principales resultados:
- Los patrones de descarga de las neuronas motoras que causan la contracción de la ESU exhiben características de un reflejo flexionador.
- Esto sugiere que un reflejo mediado por la espina es responsable de la hiperactividad de la ESU.
- Los hallazgos proporcionan una explicación neurofisiológica para la disfunción de la vejiga observada.
Conclusiones:
- El esfínter uretral externo hiperactivo en la lesión de la médula espinal está mediado por una vía de reflejo flexor.
- La comprensión de este reflejo es crucial para el desarrollo de tratamientos para los trastornos de vaciado de la vejiga en la parálisis.
- La investigación adicional puede apuntar a este reflejo para aliviar los síntomas y prevenir las ITU.
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