Video Experimental Relacionado

Updated: Jul 29, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Síndrome postpericardiotómico en adultos: incidencia, autoinmunidad y virología

M A Engle, W A Gay, J McCabe

|August 1, 1981

Resumen

El síndrome postpericardiotomy (PPS) afecta al 17,6% de los adultos, con una incidencia que disminuye con la edad. Esta condición autoinmune puede ser desencadenada por una enfermedad viral, como lo indican los anticuerpos reactivos al corazón y antivirales.

Área de la Ciencia:

Inmunología Inmunología.
Virología Virología.
Cardiología Cardiología.

Sus antecedentes:

El síndrome postpericardiotomy (PPS) es una complicación conocida después de la cirugía cardíaca.
Estudios anteriores se centraron en poblaciones pediátricas, lo que requirió una investigación en adultos.

Objetivo del estudio:

Para investigar los aspectos inmunológicos y virológicos de la PPS en una población adulta.
Para determinar la incidencia y los factores de riesgo asociados con PPS en adultos.

Principales métodos:

Se estudió una cohorte de 142 pacientes adultos sometidos a cirugía cardíaca.
La incidencia de PPS se registró y analizó en función de los grupos de edad.
Se realizaron pruebas serológicas para detectar anticuerpos reactivos al corazón y antivirales.

Principales resultados:

La incidencia de PPS en adultos fue del 17,6%, menor que el 27,8% observado en niños.
La incidencia de PPS disminuyó con el aumento de la edad, con las tasas más bajas en pacientes de 70 años o más.
Se encontraron altos títulos de anticuerpos reactivos al corazón en todos los pacientes con SPP, y el 68% mostró un aumento en los anticuerpos antivirales.

Conclusiones:

El SPP en adultos parece ser un fenómeno autoinmune.
La enfermedad viral puede actuar como un desencadenante para el desarrollo de PPS en adultos.
La edad es un factor significativo que influye en la incidencia de PPS en la población adulta.

Más Videos Relacionados

An Intact Pericardium Ischemic Rodent Model

An Intact Pericardium Ischemic Rodent Model

Published on: September 2, 2021

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

Videos de Conceptos Relacionados

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Pericarditis I: Introduction

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...

Pericarditis III: Medical Management

Pericarditis III: Medical Management

The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...