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Efecto de los cigarrillos sin nicotina y el monóxido de carbono en la angina de pecho
Circulation
|February 1, 1980
Resumen
Fumar cigarrillos sin nicotina y respirar monóxido de carbono empeoran la angina inducida por el ejercicio. Sin embargo, fumar tuvo un mayor impacto negativo en la duración del ejercicio y el rendimiento en pacientes con angina.
Área de la Ciencia:
- Cardiología Cardiología.
- Fisiología del ejercicio Fisiología del ejercicio
Sus antecedentes:
- La angina inducida por el ejercicio es un síntoma común de la enfermedad de las arterias coronarias.
- El tabaquismo y la exposición al monóxido de carbono son factores de riesgo cardiovascular conocidos.
Objetivo del estudio:
- Evaluar los efectos de fumar cigarrillos sin nicotina y respirar monóxido de carbono en la angina inducida por el ejercicio.
- Para diferenciar el impacto de la nicotina / monóxido de carbono frente a otros componentes del tabaco en la angina.
Principales métodos:
- 12 pacientes con angina de pecho se sometieron a pruebas de ejercicio.
- Las mediciones incluyeron la duración del ejercicio, la depresión del segmento ST y el producto presión arterial-ritmo cardíaco al inicio de la angina.
- Los participantes fueron expuestos a fumar cigarrillos sin nicotina y a respirar monóxido de carbono en sesiones separadas.
Principales resultados:
- Tanto el tabaquismo como la inhalación de monóxido de carbono aumentaron los niveles de carboxihemoglobina.
- Fumar redujo la duración del ejercicio en un 45% y empeoró los síntomas de angina más que el monóxido de carbono (35% de reducción).
- Fumar también condujo a mayores disminuciones en la presión arterial sistólica multiplicada por la frecuencia cardíaca en la angina.
Conclusiones:
- Los componentes del tabaco que no sean la nicotina o el monóxido de carbono contribuyen a reducir el rendimiento del ejercicio en pacientes con angina de pecho.
- Fumar exacerba la angina inducida por el ejercicio de manera más significativa que la exposición al monóxido de carbono solo.
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