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Quimioterapia para el cáncer de mama masculino avanzado
JAMA
|May 2, 1980
Resumen
El cáncer de mama masculino avanzado muestra una tasa de respuesta del 44% a la quimioterapia, similar a la de las pacientes femeninas. Los regímenes de quimioterapia de agente único fueron analizados en este estudio.
Área de la Ciencia:
- Oncología Oncología.
- Oncología médica Oncología médica.
Sus antecedentes:
- El cáncer de mama masculino es una enfermedad rara.
- Existen datos limitados sobre la eficacia de la quimioterapia en el cáncer de mama masculino avanzado.
Objetivo del estudio:
- Para analizar la tasa de respuesta del cáncer de mama masculino avanzado a la quimioterapia sistémica.
- Para comparar la eficacia de la quimioterapia en el cáncer de mama masculino frente al cáncer de mama femenino.
Principales métodos:
- Análisis de 29 ensayos quimioterapéuticos en los que participaron 18 pacientes varones con cáncer de mama avanzado.
- Evaluación de regímenes de un solo agente que incluyen fluorouracil, metotrexato, tiotepa, ciclofosfamida y melfalan.
Principales resultados:
- Se observó una tasa de respuesta general del 44% en pacientes masculinos.
- La tasa de respuesta en el cáncer de mama masculino parece comparable a la reportada para el cáncer de mama femenino.
Conclusiones:
- La quimioterapia sistémica demuestra una actividad significativa en el cáncer de mama masculino avanzado.
- El cáncer de mama masculino puede responder a la quimioterapia de manera similar al cáncer de mama femenino, lo que justifica una mayor investigación.
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