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Enfermedades virales y el síndrome postpericardiotómico. Un estudio prospectivo en niños
Circulation
|December 1, 1980
Resumen
El síndrome post-pericardiotomía (PPS) después de una cirugía cardíaca a menudo se desencadena por infecciones virales, lo que lleva a una respuesta inmune. Este estudio encontró que los anticuerpos antivirales y los anticuerpos anti-corazón aparecen simultáneamente en pacientes con SPP.
Área de la Ciencia:
- Cardiología Pediátrica Cardiología pediátrica.
- Inmunología Inmunología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- El síndrome post-pericardiotomía (PPS) es una complicación común después de una cirugía cardíaca que implica la entrada pericárdica.
- La causa exacta del PPS, ya sea viral o inmunológica, sigue siendo objeto de debate.
Objetivo del estudio:
- Para investigar la etiología viral frente a la inmunológica del síndrome post-pericardiotomía (PPS).
- Evaluar el papel de las infecciones virales y el desarrollo de anticuerpos anti-corazón (AHA) en el SPP.
Principales métodos:
- Estudio prospectivo, triple ciego, de pacientes pediátricos sometidos a cirugía intrapericárdica.
- Medición en serie de los títulos de anticuerpos anti-corazón (AHA) y anticuerpos antivirales (AVA).
- Evaluación clínica para el SPP y correlación con los hallazgos serológicos.
Principales resultados:
- La incidencia general de PPS fue del 27%, significativamente más baja (3,5%) en bebés menores de 2 años.
- El AHA de alto título estaba presente en todos los pacientes con SPP.
- Se observó un aumento significativo en los títulos de AVA en el 70% de los pacientes con SPP, lo que sugiere un desencadenante viral.
Conclusiones:
- La enfermedad viral simultánea, ya sea fresca o reactivada, probablemente desencadene la respuesta inmunológica característica del SPP.
- Los hallazgos sugieren una doble base viral e inmunológica para el síndrome post-pericardiotomía.
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