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La asociación entre los niveles de presión arterial en la mediana edad y la función cognitiva en la tercera edad. El
L J Launer1, K Masaki, H Petrovitch
1National Institute for Public Health and the Environment, Erasmus University Medical School, Bilthoven, The Netherlands.
JAMA
|December 20, 1995
Resumen
La presión arterial sistólica alta (PAS) en la mediana edad está relacionada con una peor función cognitiva más adelante en la vida. El manejo temprano de la SBP puede ayudar a prevenir el deterioro cognitivo en adultos mayores.
Área de la Ciencia:
- Gerontología Gerontología.
- Salud Cardiovascular La salud cardiovascular.
- La neurociencia es la neurociencia.
Sus antecedentes:
- La salud cardiovascular de la mediana edad es cada vez más reconocida como crucial para la función cognitiva de la tercera edad.
- Comprender el impacto a largo plazo de la presión arterial en la cognición es vital para la salud pública.
Objetivo del estudio:
- Investigar la asociación entre los niveles de presión arterial en la mediana edad y la función cognitiva en la vejez.
- Para determinar si la presión arterial sistólica (PAS) o la presión arterial diastólica (PDA) en la mediana edad predice el deterioro cognitivo.
Principales métodos:
- Estudio longitudinal de cohorte de 3.735 hombres japoneses-estadounidenses del Programa del Corazón de Honolulu.
- SBP y DBP de la mediana edad medidos entre 1965-1971; la función cognitiva evaluada con el instrumento de detección de habilidades cognitivas (CASI) en 1991-1993.
- Análisis estadístico controlado para la edad, educación, accidente cerebrovascular, enfermedad coronaria y aterosclerosis subclínica.
Principales resultados:
- El SBP más alto en la mediana edad se asoció significativamente con un mayor riesgo de función cognitiva intermedia y pobre en la tercera edad.
- Cada aumento de 10 mm Hg en el SBP de la mediana edad se correlacionó con un aumento del 7% en el riesgo de función cognitiva intermedia y un 9% de función cognitiva deficiente.
- El ajuste por factores cardiovasculares atenuó pero no eliminó el vínculo SBP-cognición; no se encontró asociación entre la DBP de la mediana edad y la función cognitiva.
Conclusiones:
- La SBP de la mediana edad es un predictor significativo de la reducción de la función cognitiva en la vida posterior.
- El manejo efectivo de la SBP en la mediana edad puede ser una estrategia clave para reducir el riesgo de deterioro cognitivo en la vejez.
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