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Selection of Aptamers for Amyloid β-Protein, the Causative Agent of Alzheimer's Disease
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La proteína relacionada con el receptor de LDL, un receptor ApoE multifuncional, se une a la proteína precursora

M Z Kounnas1, R D Moir, G W Rebeck

  • 1Department of Biochemistry, Holland Laboratories, American Red Cross, Rockville, Maryland 20855, USA.

Cell
|July 28, 1995
PubMed
Resumen

La proteína relacionada con el receptor de lipoproteína de baja densidad (LDL) (LRP) media la absorción celular y la degradación de la proteína precursora beta-amiloide secretada (APP). Este hallazgo vincula el metabolismo de LRP y APP con los factores de riesgo de la enfermedad de Alzheimer (EA).

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