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Los siete receptores transmembrana divergentes son receptores quimiosensoriales candidatos en C. elegans

E R Troemel¹, J H Chou, N D Dwyer

¹Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143-0452, USA.

|October 20, 1995

Resumen

El nematodo C. elegans utiliza un número limitado de neuronas quimiosensoriales para detectar numerosas sustancias químicas. Los investigadores identificaron más de 40 receptores acoplados a proteínas G potencialmente responsables de esta capacidad de detección química.

Área de la Ciencia:

Biología Molecular Biología Molecular
La neurociencia es la neurociencia.
La genómica es la genómica.

Sus antecedentes:

Los animales utilizan el gusto y el olfato para identificar diversos productos químicos.
El nematodo C. elegans posee 14 tipos de neuronas quimiosensoriales, cada una de las cuales detecta múltiples estímulos, lo que permite un amplio reconocimiento químico.

Objetivo del estudio:

Identificar los receptores acoplados a proteínas G (GPCR) candidatos que contribuyen a la diversidad funcional de la quimiosensibilidad en C. elegans.
Investigar la organización genómica y los patrones de expresión de estos potenciales receptores quimiosensoriales.

Principales métodos:

Análisis bioinformático para identificar GPCRs divergentes.
Análisis de la expresión génica en las neuronas quimiosensoriales de C. elegans.

Principales resultados:

Se identificaron más de 40 GPCRs divergentes como posibles receptores quimiosensoriales.
Muchos genes receptores candidatos se agrupan en el genoma.
El análisis de expresión confirmó que 11 de los 14 genes probados se expresan en subconjuntos específicos de neuronas quimiosensoriales.
Un solo tipo de neurona quimiosensorial puede expresar al menos cuatro genes receptores diferentes.

Conclusiones:

Es probable que los GPCR identificados contribuyan a las amplias capacidades de detección química de C. elegans.
Estos receptores pueden mediar respuestas a varias señales químicas, incluyendo atractivos, repelentes y feromonas.

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