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Un papel en la activación de las células B para CD22 y la proteína tirosina fosfatasa SHP
G M Doody1, L B Justement, C C Delibrias
1Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, School of Clinical Medicine, UK.
Science (New York, N.Y.)
|July 14, 1995
Resumen
La proteína CD22 en las células B actúa como un interruptor molecular. Regula la activación de las células B mediante la interacción con SHP, una fosfatasa, que influye en las respuestas inmunes.
Área de la Ciencia:
- Inmunología Inmunología.
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
Sus antecedentes:
- CD22 es una proteína asociada con la inmunoglobulina de membrana (mIg) en las células B.
- Tras la ligadura mIg, CD22 se somete a la fosforilación de la tirosina.
Objetivo del estudio:
- Para investigar el papel de CD22 en la regulación de la señalización de las células B.
- Para entender cómo CD22 influye en el umbral de activación de las células B.
Principales métodos:
- Estudiar la fosforilación de CD22 y su interacción con SHP (una proteína tirosina fosfatasa).
- Analizando el efecto de la ligadura de CD22 en la activación de las células B mediada por mIg.
- Investigando la localización de CD22 en órganos linfoides secundarios.
Principales resultados:
- La CD22 fosforilada por tirosina se une y activa SHP, que regula negativamente la señalización de mIg.
- La prevención de la coagregación de CD22 con mIg reduce el umbral de activación de las células B en 100 veces.
- CD22 puede ser secuestrado de mIg por los contraceptores de células T en los órganos linfoides.
Conclusiones:
- CD22 funciona como un interruptor molecular para SHP, modulando la señalización de las células B.
- CD22 puede dirigir la señalización mIg a áreas ricas en células T en órganos linfoides secundarios.
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