Video Experimental Relacionado
Updated: Aug 12, 2026
12:08
Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
Infección viral y cáncer
J D Morris1, A L Eddleston, T Crook
1King's College School of Medicine and Dentistry, Rayne Institute, London, UK.
Lancet (London, England)
|September 16, 1995
Resumen
Las infecciones por virus específicos pueden conducir al cáncer, pero solo si las proteínas virales interactúan con las proteínas supresoras de tumores de las células huésped. Una mayor comprensión de estas interacciones entre virus y huésped es crucial para el diagnóstico y la terapéutica del cáncer.
Área de la Ciencia:
- Oncología Oncología.
- Virología Virología.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Las infecciones virales específicas están implicadas en la patogénesis del cáncer humano.
- La incidencia de cáncer es significativamente menor que las tasas de infección por virus, lo que indica que hay factores adicionales involucrados.
Objetivo del estudio:
- Explorar los mecanismos moleculares por los cuales los virus contribuyen al desarrollo del cáncer.
- Para entender cómo las proteínas virales interactúan con las proteínas supresoras de tumores de las células huésped.
Principales métodos:
- Análisis molecular de virus asociados con el cáncer.
- Investigación de las interacciones de las proteínas virales con las proteínas de las células huésped.
Principales resultados:
- Los virus codifican proteínas que pueden unirse e interrumpir las proteínas supresoras de tumores.
- Estas proteínas virales interfieren con la detención del crecimiento de la célula huésped y las vías de apoptosis.
Conclusiones:
- La expresión de proteínas virales en tipos específicos de células o en huéspedes inmunocomprometidos puede ser crítica para el desarrollo del cáncer.
- La comprensión de estas interacciones entre virus y huésped tiene importantes implicaciones diagnósticas, pronósticas y terapéuticas para el cáncer.
Videos de Conceptos Relacionados
02:12What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...