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Enzima convertidora de angiotensina en el corazón humano. Efecto del polimorfismo de eliminación/inserción
A H Danser1, M A Schalekamp, W A Bax
1Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, COEUR, Erasmus University, Netherlands.
Circulation
|September 15, 1995
Resumen
El polimorfismo de deleción de la enzima convertidora de angiotensina (ECA) está relacionado con una mayor actividad cardíaca de la ECA en individuos con el genotipo DD. Esto puede explicar el aumento del riesgo de trastornos cardiovasculares asociados con esta variante del gen ACE.
Área de la Ciencia:
- Genética cardiovascular Genética cardiovascular Genética cardiovascular Genética cardiovascular Genética cardiovascular
- Cardiología Molecular Cardiología Molecular
Sus antecedentes:
- El polimorfismo de inserción / eliminación (I / D) del gen de la enzima convertidora de angiotensina (ACE) influye en los niveles plasmáticos de ACE.
- Este polimorfismo está implicado en enfermedades cardiovasculares como el infarto de miocardio y la enfermedad de las arterias coronarias.
Objetivo del estudio:
- Investigar la relación entre el polimorfismo del gen ACE y la actividad cardíaca de la ACE.
- Explorar posibles mecanismos que vinculan el genotipo ACE con el riesgo de enfermedad cardiovascular.
Principales métodos:
- Determinación de la actividad ACE cardíaca y el genotipo ACE en 71 sujetos con muerte no cardíaca.
- Se analizó la actividad de la ECA en diferentes genotipos de la ECA (DD, ID, II).
Principales resultados:
- La actividad cardíaca de la ECA fue significativamente mayor en sujetos con el genotipo DD (12,7 mU/g) en comparación con los genotipos ID (8,7 mU/g) y II (9,1 mU/g) (P < 0,01).
- Esta asociación fue independiente del sexo, la edad y el tiempo de recolección de tejidos.
Conclusiones:
- El genotipo DD está asociado con la actividad ACE cardíaca más alta.
- La actividad cardíaca elevada de la ECA puede aumentar los niveles cardíacos de angiotensina II, lo que potencialmente subyace a la asociación entre el polimorfismo de deleción de la ECA y el riesgo de enfermedad cardiovascular.
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