Video Experimental Relacionado
Updated: Jul 16, 2026
07:48
Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
Published on: July 3, 2015
Caracterización molecular de un receptor periférico para los cannabinoides
S Munro1, K L Thomas, M Abu-Shaar
1MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature
|September 2, 1993
Resumen
Los investigadores descubrieron un nuevo receptor cannabinoide en los macrófagos del bazo, distinto del receptor cerebral. Este hallazgo puede explicar los efectos no psicoactivos de los cannabinoides y ofrece nuevos objetivos terapéuticos.
Área de la Ciencia:
- Farmacología Farmacología.
- Inmunología Inmunología.
- La neurociencia es la neurociencia.
Sus antecedentes:
- El delta 9-tetrahidrocannabinol (delta 9-THC), un componente primario de la marihuana, tiene usos psicoactivos históricos.
- Los cannabinoides exhiben diversos efectos, incluido el alivio del dolor, la antiinflamación y la antiemesis, pero el uso clínico está limitado por la psicoactividad.
- Un receptor cannabinoide previamente identificado se encuentra principalmente en el cerebro, lo que sugiere otros mecanismos para los efectos no psicoactivos.
Objetivo del estudio:
- Identificar nuevos receptores cannabinoides involucrados en los efectos no psicoactivos de los cannabinoides.
- Para aclarar la base bioquímica de la acción de los cannabinoides más allá del receptor cerebral conocido.
Principales métodos:
- La clonación de un gen que codifica un nuevo receptor acoplado a la proteína G para los cannabinoides.
- Análisis de los patrones de expresión de los receptores en varios tejidos, centrándose en las células inmunes.
Principales resultados:
- Se clonó un nuevo receptor cannabinoide y se encontró que se expresa en los macrófagos dentro de la zona marginal del bazo.
- Este receptor está notablemente ausente en el cerebro, diferenciándolo del receptor cannabinoide previamente conocido.
- Se observó una baja expresión en los testículos, pero no en otros tejidos periféricos.
Conclusiones:
- El recientemente identificado receptor del bazo puede mediar algunos de los efectos no psicoactivos, potencialmente antiinflamatorios o inmunomoduladores, de los cannabinoides.
- Este descubrimiento abre caminos para el desarrollo de terapias basadas en cannabinoides con efectos secundarios psicoactivos reducidos.
- Se necesita más investigación para comprender completamente el papel de este receptor en la función inmune y la señalización de los cannabinoides.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:21G-protein Coupled Receptors
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
01:15G Protein-coupled Receptors
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
01:15G Protein-coupled Receptors
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
01:30Transducer Mechanism: G Protein–Coupled Receptors
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
GPCRs are also called heptahelical, 7TM, or...
01:29The Two-State Receptor Model
The two-state receptor model explains a drug's interaction with receptors, such as G protein-coupled receptors and ligand-gated ion channels, to induce or inhibit a biological response. When no natural ligands are present, a receptor exists in an equilibrium of inactive (Ri) and active (Ra) conformations. The inactive form does not produce a response, while the active form generates a basal effect known as constitutive activity.
The binding affinity of a drug determines its interaction with one...
The binding affinity of a drug determines its interaction with one...
01:22Opioid Receptors: Overview
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2, D-Pen5]-enkephalin or DPDPE for...