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La concentración plasmática de lipoproteínas y el riesgo de un futuro accidente cerebrovascular
P M Ridker1, M J Stampfer, C H Hennekens
1Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115-1204, USA.
JAMA
|April 26, 1995
Resumen
Este estudio no encontró ninguna relación entre los niveles de lipoproteína y el riesgo futuro de accidente cerebrovascular en hombres de mediana edad. La concentración de lipoproteína (Lp) no predijo el accidente cerebrovascular en esta gran cohorte prospectiva.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Epidemiología La epidemiología.
- La bioquímica es la bioquímica.
Sus antecedentes:
- La lipoproteína (Lp) es una partícula de lipoproteína implicada en la aterosclerosis.
- Los niveles elevados de Lp (a) se consideran un factor de riesgo para enfermedades cardiovasculares, incluido el accidente cerebrovascular.
- Sin embargo, la asociación específica entre la concentración basal de Lp(a) y el riesgo futuro de accidente cerebrovascular requiere una investigación prospectiva adicional.
Objetivo del estudio:
- Evaluar prospectivamente la asociación entre las concentraciones plasmáticas basales de lipoproteína (Lp) y el riesgo de accidente cerebrovascular futuro.
- Determinar si los niveles de Lp (a) pueden servir como un biomarcador predictivo para la incidencia de ictus en una cohorte masculina sana.
Principales métodos:
- Se realizó un estudio de casos y controles anidados dentro de la cohorte del Estudio de Salud de los Médicos.
- Se analizaron muestras de plasma de 198 médicos varones que sufrieron un accidente cerebrovascular para determinar la concentración de Lp.
- Los controles fueron emparejados para la edad y los hábitos de fumar, y los análisis ajustados para los factores de riesgo cardiovascular.
Principales resultados:
- No se observó ninguna diferencia significativa en la concentración o distribución mediana de Lp (a) entre los casos de accidente cerebrovascular y los controles al inicio.
- Los riesgos relativos ajustados para el accidente cerebrovascular a través del aumento de los percentiles Lp (a) fueron consistentemente no significativos.
- No se encontró asociación entre Lp(a) y el riesgo de accidente cerebrovascular, incluidos los eventos tromboembólicos, o en análisis estratificados por hipercolesterolemia.
Conclusiones:
- La concentración basal de lipoproteínas plasmáticas no se asocia con un mayor riesgo de accidente cerebrovascular total o tromboembólico futuro en hombres predominantemente blancos, sanos y de mediana edad.
- Estos hallazgos sugieren que Lp (a) puede no ser un predictor independiente significativo de accidente cerebrovascular en esta población.
- Puede ser necesaria una investigación adicional para explorar las asociaciones Lp (a) en diversas poblaciones o subtipos específicos de ictus.
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