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El kala-azar indio es causado por Leishmania tropica
D L Sacks1, R T Kenney, R D Kreutzer
1Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lancet (London, England)
|April 15, 1995
Resumen
La Leishmania tropica, y no sólo la Leishmania donovani, causa la leishmaniasis visceral en la India. Este hallazgo puede explicar los fracasos del tratamiento en los pacientes de Kala-azar que reciben gluconato de antimonio sódico.
Área de la Ciencia:
- Parasitología Parasitología.
- La Medicina Tropical es una medicina tropical.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- El Kala-azar (leishmaniasis visceral) en la India es típicamente atribuido a Leishmania donovani.
- Comprender las especies de Leishmania causantes es crucial para un diagnóstico y tratamiento efectivos.
Objetivo del estudio:
- Para investigar las especies de parásitos Leishmania responsables de la leishmaniasis visceral en la India.
- Para determinar si la Leishmania tropica juega un papel en los casos de leishmaniasis visceral en la India.
Principales métodos:
- Análisis de 15 aislamientos del parásito Leishmania de pacientes indios con leishmaniasis visceral.
- Los métodos de tipificación incluyeron anticuerpos monoclonales, análisis de isoenzimas y análisis de kDNA.
Principales resultados:
- Cuatro de los 15 aislamientos fueron identificados como Leishmania tropica.
- La Leishmania tropica está históricamente vinculada a la leishmaniasis cutánea, pero se ha observado en enfermedades visceralizantes.
Conclusiones:
- La Leishmania tropica es una causa coendémica de la leishmaniasis visceral en la India.
- La presencia de Leishmania tropica puede contribuir a la creciente falta de respuesta terapéutica al gluconato de sodio antimonio.
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