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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
Published on: April 18, 2016
El receptor DEC-205 expresado por las células dendríticas y las células epiteliales del timo está involucrado en el
W Jiang1, W J Swiggard, C Heufler
1Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA.
Nature
|May 11, 1995
Resumen
Las células dendríticas y las células epiteliales del timo utilizan el nuevo receptor endocítico DEC-205 para capturar y presentar diversos antígenos. Este receptor dirige los antígenos a compartimentos especializados, mejorando las respuestas de las células T.
Área de la Ciencia:
- Inmunología Inmunología.
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Las células dendríticas (DC) y las células epiteliales del timo (TEC) son cruciales para la regulación inmune a través de la presentación de antígenos.
- Anteriormente no se había descrito un mecanismo específico para la captura y presentación de antígenos por DC y TEC.
- Las células B presentan eficazmente los antígenos a través de las inmunoglobulinas de superficie.
Objetivo del estudio:
- Identificar un nuevo mecanismo para la captura y presentación de antígenos por DC y TEC.
- Para investigar el papel de la proteína DEC-205 en la presentación del antígeno.
Principales métodos:
- Investigó la expresión y función de DEC-205 en DC y TEC.
- Se utilizaron anticuerpos dirigidos a DEC-205 para estudiar la captación y presentación de antígenos.
- Evaluación de la eficiencia de la presentación de antígenos mediante el uso de híbridosomas de células T.
Principales resultados:
- Las células dendríticas y las células epiteliales del timo expresan altos niveles de DEC-205.
- DEC-205 media la endocitosis rápida de las moléculas unidas a través de fosas y vesículas recubiertas.
- Los antígenos unidos por DEC-205 se presentan 100 veces más eficientemente a las células T.
Conclusiones:
- DEC-205 es un nuevo receptor endocítico involucrado en la captura y presentación de antígenos.
- DEC-205 dirige los antígenos extracelulares a un compartimiento endosómico especializado para su procesamiento.
- Este mecanismo mejora la capacidad de las DC y las TEC para presentar diversos antígenos a las células T.
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