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Updated: Aug 15, 2026

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
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OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

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Reposicionamiento de un dominio en una poliquetida sintasa modular para promover la escisión específica de la cadena

J Cortes1, K E Wiesmann, G A Roberts

  • 1Cambridge Centre for Molecular Recognition, University of Cambridge, UK.

Science (New York, N.Y.)
|June 9, 1995
PubMed
Resumen

Los investigadores modificaron la 6-deoxyeritronolide B sintasa (DEBS) para controlar la síntesis de policetida. El reposicionamiento de un dominio ciclasa aceleró la formación de estructuras específicas de policetídeos, ofreciendo un nuevo método para el desarrollo de fármacos.

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