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La asociación de los parámetros fibrinolíticos con la aterosclerosis temprana. El estudio ARIC. Riesgo de
V Salomaa1, V Stinson, J D Kark
1Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Circulation
|January 15, 1995
Resumen
Este estudio sugiere que la trombosis y el deterioro de la fibrinólisis, indicado por niveles más altos de PAI-1, TPA y D-dimero, están relacionados con el desarrollo temprano de la aterosclerosis.
Área de la Ciencia:
- Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular Investigación Cardiovascular
- Hematología Hematología.
- Biología Vascular Biología Vascular
Sus antecedentes:
- La progresión de la aterosclerosis está relacionada con la ruptura de la placa y la trombosis.
- El papel de la trombosis y la fibrinólisis en la aterosclerosis temprana sigue sin estar claro.
- La fibrinólisis defectuosa puede contribuir al desarrollo de lesiones ateroscleróticas.
Objetivo del estudio:
- Para investigar la asociación entre los marcadores de trombosis/fibrinólisis y la aterosclerosis temprana.
- Para determinar si los niveles de PAI-1, TPA y D-dimero se correlacionan con el grosor de la carótida íntima-media.
Principales métodos:
- Estudio transversal de casos y controles de 457 parejas de la cohorte ARIC.
- Los casos tenían un espesor carotídeo íntima-medio >90o percentil; los controles tenían <75o percentil.
- Se midió el antígeno inhibidor del activador del plasminógeno (PAI-1), el antígeno activador del plasminógeno tipo tejido (TPA) y el D-dimer.
Principales resultados:
- Los niveles de PAI-1, TPA y D-dimero fueron significativamente más altos en los casos que en los controles.
- Se observaron mayores proporciones de probabilidades para la aterosclerosis carotídea con cuartiles más altos de PAI-1, TPA y D-dimer.
- Una tendencia lineal significativa apoyó la asociación entre estos marcadores y la aterosclerosis.
Conclusiones:
- Los hallazgos apoyan la hipótesis de que la trombosis y la fibrinólisis están involucradas en la aterosclerosis temprana.
- Los factores trombóticos y fibrinolíticos pueden desempeñar un papel en las etapas iniciales del desarrollo de la lesión aterosclerótica.
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