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Videos de Conceptos Relacionados

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Drug Concentrations: Measurements01:23

Drug Concentrations: Measurements

Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

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Video Experimental Relacionado

Updated: Jul 18, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

Pruebas de campo para el uso racional de drogas en doce países en desarrollo.

H V Hogerzeil1, Bimo, D Ross-Degnan

  • 1World Health Organization, Action Programme on Essential Drugs, Geneva, Switzerland.

Lancet (London, England)
|December 4, 1993
PubMed
Resumen

Este estudio introduce indicadores de uso de drogas para las naciones en desarrollo, ayudando a una mejor prescripción y uso de drogas. Estos indicadores ayudan a crear conciencia, identificar problemas como la polifarmacia y medir la efectividad de la intervención.

Palabras clave:
Los antibióticos son los antibióticos.Recopilación de datos Recopilación de datosLa prestación de cuidados de salud.Países en desarrollo Países en desarrollo.Actividades de distribución Las actividades de distribución.Drogas Las drogas son drogas.Salud Salud Salud Salud Salud Salud SaludInstalaciones de salud Instalaciones de salud.Rehidratación Oral por Rehidratación OralOrganización y administración de la organización y administración.Las prescripciones - estándares.Actividades del programa Actividades del programaLos programas de los programas.Metodología de investigación Metodología de investigación.Centros de salud rurales.Tratamiento El tratamiento.

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Área de la Ciencia:

  • Salud Global La salud global.
  • Farmacoeconomía La farmacoeconomía es la economía de las drogas.
  • Servicios de salud Servicios de salud Investigación Investigación.

Sus antecedentes:

  • Mejorar el uso de drogas y la prescripción en los países en desarrollo es una prioridad de salud mundial.
  • Las herramientas de evaluación objetiva son cruciales para evaluar y mejorar las prácticas de consumo de drogas.

Objetivo del estudio:

  • Presentar un conjunto de indicadores de consumo de drogas desarrollados y validados en doce países en desarrollo.
  • Demostrar las aplicaciones prácticas de estos indicadores en diversos entornos de atención médica.

Principales métodos:

  • Desarrollo y prueba de un conjunto estandarizado de indicadores de uso de drogas.
  • Aplicación de indicadores en doce países en desarrollo para la evaluación y la evaluación de las intervenciones.

Principales resultados:

  • Se utilizaron indicadores para aumentar el conocimiento de los prescriptores en Malawi y Bangladesh.
  • Las prioridades identificadas incluyeron la polifarmacia (Indonesia, Nigeria), el uso excesivo de inyecciones (Uganda, Sudán, Nigeria) y la mala comprensión de los pacientes de los esquemas de dosificación (Malawi).
  • Impacto de la intervención cuantificada en Yemen, Uganda, Sudán y Zimbabue.

Conclusiones:

  • Los indicadores de uso de drogas desarrollados proporcionan una herramienta valiosa para mejorar el comportamiento de prescripción y el uso de drogas en los países en desarrollo.
  • Estos indicadores facilitan las intervenciones específicas y el monitoreo de la calidad de la atención médica.