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¿Es la cirrosis infantil no india causada por el exceso de cobre en la dieta?
1National Center for the Study of Wilson's Disease, Columbia University, New York, NY 10019.
Lancet (London, England)
|October 8, 1994
Resumen
La cirrosis infantil no india no es causada por altos niveles de cobre en el agua potable. La evidencia sugiere que este trastorno del hígado en los bebés es en realidad hereditaria.
Área de la Ciencia:
- Hepatología Hepatología.
- Salud Ambiental Salud del medio ambiente.
- Genética La genética.
Sus antecedentes:
- La cirrosis infantil india está relacionada con la ingesta excesiva de cobre de la leche hervida en vasos de cobre.
- Los casos de cirrosis infantil no indígenas se han atribuido al cobre en el agua potable, con niveles reportados que oscilan entre 0,05 y 6,8 mg Cu/L.
Objetivo del estudio:
- Investigar la asociación entre los altos niveles de cobre en el agua potable y la cirrosis infantil no indígena.
- Determinar los factores etiológicos de la cirrosis infantil no indígena.
Principales métodos:
- Análisis retrospectivo de los niveles de cobre en el agua potable en tres ciudades de Massachusetts (1969-1991).
- Examen de los datos de mortalidad de niños menores de 6 años expuestos a agua potable con 8,5-8,8 mg Cu/L.
- Revisión de informes de casos previos sobre cirrosis infantil no indígena.
Principales resultados:
- No se observaron muertes por cirrosis o enfermedad hepática en 64.124 niños-años de exposición a agua potable con alto contenido de cobre (8,5-8,8 mg Cu/L).
- Informes previos de cirrosis infantil no indígena incluían bebés con posibles predisposiciones genéticas.
- La incidencia de la cirrosis no aumentó a pesar de la alta exposición al cobre.
Conclusiones:
- Es poco probable que los altos niveles de cobre en el agua potable sean la causa de la cirrosis infantil no indígena.
- La cirrosis infantil no indígena parece ser un trastorno hereditario, no un problema de toxicidad ambiental.
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