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La hemoglobina A1, la glucosa en sangre y el colesterol de lipoproteínas de alta densidad en diabéticos que requieren
Lancet (London, England)
|September 9, 1978
Resumen
Los niveles de hemoglobina A1 glicada (HbA1) se correlacionan con la glucosa en sangre en los diabéticos. Sin embargo, la HbA1 no predice de manera confiable los niveles de colesterol de lipoproteína de alta densidad (HDL) en estos pacientes.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Enfermedades Metabólicas Las enfermedades metabólicas.
- Química clínica es la química clínica.
Sus antecedentes:
- El manejo de la diabetes mellitus requiere monitorear el control glucémico.
- La hemoglobina glicada A1 (HbA1) refleja los niveles de glucosa en sangre a largo plazo.
- El colesterol de lipoproteínas de alta densidad (HDL) es un factor de riesgo cardiovascular clave.
Objetivo del estudio:
- Para investigar la correlación entre los niveles de HbA1 y de glucosa en sangre.
- Para examinar la relación entre HbA1, glucosa en sangre y colesterol HDL en diabéticos que requieren insulina.
- Para evaluar la HbA1 como un predictor de la concentración de colesterol HDL.
Principales métodos:
- El estudio incluyó a cuarenta pacientes diabéticos que requerían insulina.
- Se midió la HbA1 y la glucosa sanguínea concurrente.
- Glucosa en sangre clínica media estimada durante el año anterior.
- Se midió la concentración de colesterol de lipoproteínas de alta densidad (HDL).
Principales resultados:
- Se encontró una correlación significativa entre HbA1 y la glucosa en sangre concurrente.
- Se observó una correlación significativa entre la HbA1 y la glucosa sanguínea promedio clínica durante el año anterior.
- No se detectó una correlación significativa entre las concentraciones de colesterol HbA1 y HDL.
- No se encontró una correlación significativa entre la concentración de glucosa en sangre y el colesterol HDL.
Conclusiones:
- La HbA1 es un indicador fiable del control glucémico reciente en diabéticos que requieren insulina.
- La HbA1 no es un predictor adecuado para los niveles de colesterol HDL en este grupo de pacientes.
- La evaluación del colesterol HDL requiere una medición directa, independiente de los marcadores de control glucémico como HbA1.1.
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